Bone Tissue Regeneration Using a Single Molecule Adenosine

Bones are basic structures, which holds almost all the bodies on this planet, Earth. Bone defects in human beings are raising because of the changing lifestyles. Aging, obesity and lack of physical activity are the main reasons for bone defects. The study made by the researchers from California proves to be groundbreaking in such a scenario. Bone tissues can now be regenerated using a single molecule.

A team of researchers from the University of California in San Diego has discovered that a single molecule could be used to regenerate bone tissue. The process is speedier and efficient than bone grafts. Bone grafting is the surgical procedure used to fix problems with bones or joints. Bone grafting is the only solution available until the researchers came up with the new solution.

The researchers have identified the molecule adenosine, as a solution for bone defects. Adenosine is a naturally occurring molecule. Researchers have discovered that adenosine can be injected into bone tissue to coax human pluripotent stem cells. Pluripotent stem cells are capable of regenerating any type of cell in the body. In the experiment, this method helped fix cranial bone defects in mice. Additionally, without causing infections or tumors.

Pluripotent stem cells possess the capability of producing any type of cells in a body through differentiation. Such a process of stem cell differentiation, however, is very complicated and expensive. The method is also known to cause the development of teratomas. Teratomas are tumors that contain multiple tissues taken from various organs upon transplantation.

The researchers have managed to perform stem cell differentiation by just adding adenosine to pluripotent stem cells. Hence, this method proves to be cost efficient besides, being a faster process. Shyni Varghese said, “One of the broader goals of our research is to make regenerative treatments more accessible and clinically relevant by developing easy, efficient and cost-effective ways to engineer human cells and tissues.” Shyni Varghese is a bioengineering professor at UC San Diego and senior author of the study.

Using a single molecule to regenerate a bone tissue is a significant leap in the field of regenerative medicine.



Shobith MAKAM Written by:

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