Fertility Restores in Mice – 3D Printed Ovary

The technological advancements include the ability to be able to print anything in a three-dimensional model. Evidently, such innovation is a breakthrough in the history of printing. Another innovation in the sphere of three-dimensional printing has been invented by the researchers of North Western University. The team of researchers has managed to print 3D ovaries. These ovaries when injected into the infertile mice, were able to resume their reproduction cycle and were able to give birth.

The team presented the results of the experimental implantation procedure during the annual meeting of the Endocrine Society. Lead study author Monica M. Laronda, Ph.D. explained in an announcement. National hormone research group that the 3D-printed implant was developed “with downstream human applications in mind,” and that the team hopes to “one day restore fertility and hormone function in women who suffer from the side effects of cancer treatments or who were born with reduced ovarian function.”

Laronda further explained that “One of the biggest concerns for patients diagnosed with cancer is how the treatment may affect their fertility and hormone health.” “We are developing new ways to restore their quality of life by engineering ovary bioprosthesis implants.”

The researchers used gelatin, a biological material derived from animal protein collagen. The gelatin- made scaffold structure, supports the cell types and is flexible and porous enough to allow oocyte growth, ovulation, and the formation of blood vessels throughout. Thereby making the implant hospitable to both immature egg cells (or “oocytes”) and hormone-producing cells found in biological ovaries. Consequently, 3D printed prosthetic ovary for seeding egg and hormone production, was firm to handle during the surgery. This surgery was made on mice, whose ovaries are removed.

The results of the experiment have been path breaking and have enabled the infertile mice to restore its fertility. Thereby, allowing the mice to give birth to pups.

Scientists claim that there are high possibilities of observing the similar results in women. Because mice have many biological and reactionary similarities to humans.

 

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Shobith MAKAM Written by: